A Biologically Based Model for Liver Cancer Risk in the Swedish Thorotrast Patients

The induction of heme oxygenase-1 (HO-1) has been shown to have therapeutic potential in experimental models of hepatitis and liver fibrosis, which are closely related to liver cancer. In humans, HO-1 induction is transcriptionally modulated by the length of a GT-repeat [(GT)n] in the promoter region. We aimed to investigate the effect of HO-1 (GT)n variants on liver cancer in a human population. We determined the HO-1 genotype in 1153 study subjects and examined their association with liver cancer risk during a 15.9-year follow-up. Allelic polymorphisms were classified as short [S, <27 (GT)n] or long [L, ≥27 (GT)n]. Newly developed cancer cases were identified through linkage to the National Cancer Registry of Taiwan. Multivariate Cox regression analysis was used to evaluate the effect of the HO-1 (GT)n variants. Alpha-fetoprotein (AFP) and cirrhosis history were also examined. The S/S genotype was found to be significantly associated with liver cancer risk, compared to the L/S and L/L genotypes. The S/S genotype group also had a higher percentage of subjects with abnormal AFP levels than other groups. There were significant percentages of cirrhosis among groups who carried S-alleles. Our findings indicate that short (GT)n variants in the HO-1 gene may confer susceptibility to rather than protection from liver cirrhosis/cancer.

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Press Release: Hepatitis B Viral Load, Genotype Affect Liver Cancer Risk, Study Finds

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/97.4.241-b ◽

2005 ◽

Vol 97 (4) ◽

pp. 241-241

Author(s):

S. L. Zielinski

Keyword(s):

Viral Load ◽

Liver Cancer ◽

Hepatitis B ◽

Cancer Risk ◽

Press Release

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Pre‐diagnostic urinary 15‐F 2t ‐isoprostane level and liver cancer risk: Results from the Shanghai Women's and Men's Health Studies

International Journal of Cancer ◽

10.1002/ijc.31591 ◽

2018 ◽

Vol 143 (8) ◽

pp. 1896-1903 ◽

Cited By ~ 1

Author(s):

Xiao Ma ◽

Yu‐Ting Tan ◽

Yang Yang ◽

Jing Gao ◽

Hong‐Lan Li ◽

...

Keyword(s):

Liver Cancer ◽

Cancer Risk ◽

Men’S Health ◽

Men's Health ◽

Health Studies

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The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case–control study and meta-analysis

Bioscience Reports ◽

10.1042/bsr20180853 ◽

2018 ◽

Vol 38 (6) ◽

Cited By ~ 4

Author(s):

Bifeng Chen ◽

Shang Wang ◽

Guangxin Ma ◽

Jin Han ◽

Jingli Zhang ◽

...

Keyword(s):

Prostate Cancer ◽

Lung Cancer ◽

Liver Cancer ◽

Cancer Risk ◽

Cancer Patients ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

A Genome ◽

Control Study

How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case–control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.

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